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iBioSign Health Integrated Systems Corporation™

Depression During and After Pregnancy

Sound Induced Signature Motifs and Neurotransmission Pathways: A sentinel approach to mental health during and after pregnancy

In recent years, commendable efforts have been made to raise awareness and acceptance of individuals suffering from a variety of mental illnesses across North America. Nonetheless, the early onset of mild to severe depression in women during and after pregnancy remains largely undisclosed, misunderstood and / or unattended. Recent estimates reveal that up to 16% of pregnant women and 12% to 48% of mothers with young children suffer from mild to severe depression during and after pregnancy, leading to significant and long-term health concerns affecting both mothers and newborn infants (1-4).

Although there is mounting clinical evidence of the positive effects of individual music therapy for depression, pain tolerance, pleasurable reward and emotion in accordance to experimental data obtained through prospective randomized controlled trials (3, 5, 6), to date, there is a lack of quantifiable clinical evidence correlating discrete individual choices or musical preferences with consistent desirable outcomes.

Based upon seven original pieces using discrete harmonic overtones, iBioSign™ developed a novel interactive tool under the putative name of Sound-Induced Signature Motifs and Neurotransmission Pathways™. Hosted within our interactive centric database, the iBioSign Health Profile Navigator™, the Sound-Induced Signature Motifs'™ harmonic-overtone functionality provides a set of quantitative parameters with which to better correlate discrete individual changes of musical preferences with early behavioural changes, potentially revealing the early onset of depression in women during and after pregnancy.

In addition to providing a non-intrusive, objective and quantifiable method for the early detection of changes in behavioural patterns indicative of the early onset of depression, a closer monitoring of nutritional factors influencing depression will be able to be established during and after pregnancy in an effort to curb this ailment.

Each enrolment into our iBioSign Health Profile Navigator™ and purchase of our CD, Believe: Sound-Induced Signature Motifs, will make a direct impact in better addressing the mental and overall health of pregnant women and their infants.

Thank you for joining us.

Contact us for more information.


1. Arya, R., Chansoria, M., Konanki, R. and Tiwari, D.K. (2012) Maternal Music Exposure during Pregnancy Influences Neonatal Behaviour: An Open-Label Randomized Controlled Trial. International Journal of Pediatrics, 2012, Article ID 901812, 6 pages doi: 10, 1155/2012/901812.

2. Chung, E.K., McCollum, K.F., Elo, I.T., Lee, H.J. and Culhane, J.F. (2004) Maternal Depressive Symptoms and Infant Health Practices Among Low-Income Women. Pediatrics 113 (6) e523-e529.

3. Field T. (1998) Maternal Depression Effects on Infants and Early Interventions. Preventative Medicine 27, 200-203.

4. Zlotnick, C., Johnson, S.L., Miller, I.W. Pearlstein, T. and Howard, M. (2001) Postpartum Depression in Women Receiving Public Assistance: Pilot Study of an Interpersonal-Therapy-Oriented Group Intervention. American J. Psychiatry 2001, 158, 638-640.

5. Erkkilä, J., Punkanen, M., Fachner, J., Ala-Ruona, E., Pöntiö, I., Tervaniemi, M., Vanhala, M. and Gold, C. (2011) Individual music therapy for depression: randomised controlled trial. The British Journal of Psychiatry 199, 132-139. Doi 10.1192/bjp.bp 110.085431.

6. Blood, A.J. and Zatorre, R.J. (2001) Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion. PNAS 98 (20) 11818-11823.